Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emergence of a mixed CAF population by FAP-CD3 T-cell engager limits therapeutic efficacy.

Journal for immunotherapy of cancer·2026

Same author

EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi-Omics and Experimental Study.

Clinical and translational science·2026

Same author

Atmospheric bulk deposition of microplastics in Jiuzhaigou World Natural Heritage Site: Tourism-associated divergence between particle number and polymer mass fluxes.

Journal of hazardous materials·2026

Same author

Application of ultrasound and methylation omics detection in the diagnosis of endometrial cancer.

Frontiers in oncology·2026

Same author

Spatially confined multi-enzyme cascade nanoreactor for portable and real-time pesticide detection.

Journal of nanobiotechnology·2026

Same author

Comparative Evaluation of Packing Models for Mix Design and Performance Optimization of Ceramsite-Modified Lightweight Ultra-High-Performance Concrete.

Materials (Basel, Switzerland)·2026

Same journal

Research hotspots and trend analyses of maximum biosafety level pathogens: A bibliometric study using China's 2023 catalogue of pathogens as an example.

Biosafety and health·2026

Same journal

Building internationally competitive journals for science data sharing: The evolution of three biomedical English academic journals launched in China.

Biosafety and health·2026

Same journal

Genomic phylogenetic characterization of <i>Brucella abortus</i> biovar 1 from a human case in Yunnan Province, China.

Biosafety and health·2026

Same journal

Establishment and application of a rapid and visual detection method for <i>Mycoplasma pneumoniae</i> using enzymatic recombinase amplification combined with lateral flow dipstick.

Biosafety and health·2026

Same journal

A semi-quantitative risk assessment of pathogenic microorganism laboratories in Beijing's CDCs based on a three-dimensional risk matrix model.

Biosafety and health·2026

Same journal

Cellular miR-24-3p inhibits vaccinia virus replication by targeting kinesin-like protein KIF21B.

Biosafety and health·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 22, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

A secure visualization platform for pathogenic genome analysis with an accurate reference database.

Guomei Fan^1,2, Chongye Guo^1,2, Qian Zhang^1,2

¹Microbial Resource and Big Data Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Biosafety and Health

|March 13, 2025

Summary

This summary is machine-generated.

A secure system for pathogen genomic analysis aids global health security. It enables detailed investigation of pathogen transmission, evolution, and emerging strains for better infectious disease control.

Keywords:

Horizontal transfer One-stop analysis tools Pathogen surveillance Secure computing Sequence typing

More Related Videos

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

Related Experiment Videos

Last Updated: May 22, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

Area of Science:

Genomic epidemiology and bioinformatics
Infectious disease surveillance
Computational biology and data security

Background:

Genomic data is fundamental for understanding pathogen characteristics, transmission, and epidemiological trends.
Effective pathogen surveillance is critical for global health security and infectious disease control.
Existing analytical tools may lack the necessary security for highly pathogenic organisms.

Purpose of the Study:

To develop a secure visualization system for comprehensive pathogen genomic analysis.
To enable secure analysis of pathogen data, including genome assembly, annotation, and resistance profiling.
To support in-depth investigations into pathogen evolution, transmission, and emerging strains.

Main Methods:

Designed a secure visualization system for pathogen genome assembly, annotation, species identification, and sequence typing.
Integrated antibiotic resistance and virulence analysis, mobile element annotation, and phylogenetic tree reconstruction.
Developed a secure computing tool using trusted execution environments, blockchain, and privacy-preserving technologies for nucleotide basic local alignment search tool (BLASTn) analysis.

Main Results:

The system provides a secure platform for diverse pathogen genomic analyses.
The secure computing tool ensures data protection for highly pathogenic organisms during BLASTn comparisons.
The technological advancement supports detailed investigations into pathogen transmission, evolution, and immune evasion.

Conclusions:

The developed secure system and tools offer scientific support for pathogen surveillance and control.
This advancement aids in identifying new and emerging pathogen strains, enhancing infectious disease prevention and research.
The system contributes to strengthening global health security through advanced genomic analysis capabilities.