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Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway

Dan Long1, Chenhan Mao2, Wei Zhang1

  • 1Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Frontiers in Immunology
|March 13, 2025
PubMed

Insights

Ulcerative colitis (UC) pathogenesis involves the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Natural products targeting this pathway offer promising therapeutic strategies for UC treatment.

Area of Science:

  • Immunology
  • Gastroenterology
  • Pharmacology

Background:

  • Ulcerative colitis (UC) is an autoimmune disease with complex pathogenesis.
  • The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is crucial in immune responses and inflammation, and is implicated in UC.
  • Understanding the JAK/STAT pathway's role in UC is vital for developing effective treatments.

Purpose of the Study:

  • To review the current research on the JAK/STAT signaling pathway in the context of ulcerative colitis.
  • To systematically summarize recent studies on natural products that target the JAK/STAT pathway for UC treatment.
  • To explore novel therapeutic strategies for UC drug development by modulating the JAK/STAT pathway.

Main Methods:

  • Literature review of studies on JAK/STAT signaling in UC.
  • Systematic summary of research on natural products targeting the JAK/STAT pathway for UC.
  • Identification and analysis of active ingredients from natural products with potential therapeutic effects.

Main Results:

  • The JAK/STAT pathway significantly influences UC by regulating intestinal inflammation, mucosal barrier function, T cell homeostasis, and macrophage activity.
  • Numerous natural products, including arbutin, aloe polysaccharide, berberine, matrine, curcumin, and Ginsenoside Rh2, show potential in targeting the JAK/STAT pathway for UC.
  • These natural products offer multi-targeted therapeutic benefits and diverse treatment modalities.

Conclusions:

  • The JAK/STAT pathway is a key player in the pathogenesis of ulcerative colitis.
  • Natural products represent a promising avenue for developing novel, multi-targeted therapies for UC by modulating the JAK/STAT pathway.
  • Further research into these natural compounds could lead to new drug development strategies for UC.
Keywords:
Janus kinase (JAK)natural productssignal transducer and activator of transcription (STAT)traditional herbal medicineulcerative colitis

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