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Published on: January 19, 2016
Fluorine-Based Oxidant Enables Room-Temperature Pd-Catalyzed C-H Arylation with Boronic Acids
Delphine S Pichon-Barré1, Nicholas R McDonald1, Erik A Romero1
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0309, United States.
Abstract:
The biaryl motif is important in many fields within chemistry and the life sciences. Thus, better strategies to forge aryl-aryl bonds are valuable. Herein, we report conditions permitting the room temperature arylation of N-aryl amide substrates, using ubiquitous aryl boronic acid reagents. Critical to the success of this method is the use of Selectfluor as a sustainable alternative oxidant to silver-based additives and the deployment of a bulky QuinOx ligand supporting the palladium catalyst.
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