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Updated: May 22, 2025
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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
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Nanophotonic platform for the highly sensitive detection of trypsin enzyme in human urine
Shrishty Bakshi1, Kezheng Li1, Pankaj K Sahoo1
1School of Physics, Engineering and Technology, University of York, York, YO10 5DD, UK. shrishty.bakshi@york.ac.uk.
Chemical Communications (Cambridge, England)
|March 13, 2025
Abstract:
Trypsin is an important indicator of pancreatic disease. We introduce a nanophotonic test for the detection of trypsin. Our approach is based on the hydrolysis of β-casein by trypsin. We demonstrate 0.1 ng mL-1 of trypsin detection in human urine and across the clinically relevant range.
