Related Experiment Video
Updated: Jun 14, 2026
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Trends and Outcomes Following Percutaneous Coronary Intervention in Patients With Myeloproliferative Neoplasms:
Song Peng Ang1, Jia Ee Chia2, Chayakrit Krittanawong3
1Department of Internal Medicine, Rutgers Health/Community Medical Center, Toms River, New Jersey, USA.
Insights
Patients with myeloproliferative neoplasms (MPN) undergoing percutaneous coronary intervention (PCI) have stable prevalence but increased risks of blood transfusions and acute kidney injury (AKI). Further research is needed to improve outcomes for this high-risk group.
Area of Science:
- Cardiology
- Hematology
- Clinical Research
Background:
- Myeloproliferative neoplasms (MPN) increase cardiovascular risk, including acute coronary syndrome.
- Limited data exists on percutaneous coronary intervention (PCI) rates, characteristics, and outcomes in MPN patients.
Purpose of the Study:
- To evaluate temporal trends and outcomes of PCI in patients with MPN.
- To compare in-hospital characteristics and outcomes between MPN and non-MPN patients undergoing PCI.
Main Methods:
- Utilized the National Inpatient Sample database (2016-2020) for PCI hospitalizations.
- Analyzed temporal trends and outcomes, employing propensity score matching (PSM) for comparison.
- Included 2,237,210 PCI hospitalizations, with 7,560 (0.27%) involving patients with MPN.
Main Results:
- MPN prevalence among PCI admissions remained stable (0.27%) from 2016-2020.
- MPN patients had higher rates of cardiovascular comorbidities.
- Post-PSM, MPN was linked to increased risk of blood transfusions (OR: 1.66) and acute kidney injury (AKI) (OR: 1.39).
Conclusions:
- MPN prevalence in PCI patients is stable, but associated with higher risks of blood transfusion and AKI.
- In-hospital mortality and bleeding risks did not significantly differ between MPN and non-MPN groups post-PSM.
- Further investigation is crucial to understand and mitigate increased risks in MPN patients undergoing PCI.
Background:
Myeloproliferative neoplasms (MPN) are associated with an increased cardiovascular risk including acute coronary syndrome. However, there is a lack of comprehensive data regarding the rate of percutaneous coronary intervention (PCI), as well as the in-hospital characteristics and outcomes for MPN patients.
Aims:
We aimed to evaluate the temporal trends and outcomes of PCI among patients with MPN.
Methods And Results:
The National Inpatient Sample database from 2016 to 2020 was queried to identify all PCI hospitalizations. Temporal trends and outcomes of patients with and without MPN following PCI were analyzed. Propensity score matching (PSM) was implemented to compare outcomes between MPN and non-MPN groups. 2,237,210 PCI hospitalizations with 7560 (0.27%) patients with MPN were included in this study. Throughout the study period, the prevalence of MPN among PCI admissions remained stable (p-value for trend = 0.12). Within the MPN subgroup, essential thrombocythemia (ET) was the predominant condition (53.2). Patients with MPN had higher prevalence of cardiovascular comorbidities than non-MPN patients. Following PSM, MPNs were significantly associated with a higher risk of blood transfusions (OR: 1.66, 95% CI: 1.22-2.24, p = 0.001) and AKI (OR: 1.39, 95% CI: 1.17-1.65, p < 0.001). In contrast, the risk of in-hospital mortality (OR: 1.18, 95% CI: 0.83-1.69, p = 0.354 and bleeding (OR: 1.43, 95% CI: 0.90-2.27, p = 0.127) did not significantly differ between the two groups.
Conclusions:
Our study demonstrated that while the prevalence of MPN among patients undergoing PCI remained stable, those with MPN faced higher risks of bleeding, blood transfusion and acute kidney injury. Further research is warranted to explore the underlying reasons for these increased risks and to improve outcomes in this high-risk group.
More Related Videos
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
