Related Experiment Video
Updated: May 22, 2025
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
Published on: September 12, 2014
Allogeneic composite amniotic membrane in tympanic membrane repair: a randomized parallel controlled study
Anchi Sun1,2, Rongrong Lv1,2, Zhiwei Xing1
1Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Backgrounds:
Composite amniotic membranes have been widely used in ophthalmology and orthopedics. For the repair of tympanic membrane perforation, the introduction of amniotic membrane is still under study.
Objectives:
To analyse the effectiveness of a homograft composite amniotic membrane in tympanic membrane repair.
Methods:
A total of 76 patients were recruited and randomly assigned to the experimental group (n = 39) and the control group (n = 37). The test group employed a composite amniotic membrane for the repair of the tympanic membrane, while the control group utilized cartilage from the auricular for the same purpose. The efficacy of composite amniotic membrane was evaluated through a comparative analysis of postoperative tympanic membrane healing, complications, and hearing recovery.
Results:
Hearing improved significantly in both groups, but there was no significant difference between the two groups. The results of the postoperative pain scores demonstrated that the majority of patients were experiencing mild pain, with a notable discrepancy between the test group and the control group. Intraoperative bleeding time was also significantly lower in the test group than in the control group.
Conclusion:
Allogeneic composite amniotic membrane can be used as a material for repairing tympanic membrane perforation, which can effectively improve postoperative hearing of patients.
