Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

174
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
174
Seizures: Classification01:13

Seizures: Classification

297
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
297
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

300
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
300
Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

1.4K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis....
1.4K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

266
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
266
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

843
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
843

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed and deferred surgery associated with cenobamate use in people with drug-resistant focal epilepsy.

Epilepsia·2026
Same author

Cerebellar involvement and stimulation in epilepsy.

Current opinion in neurology·2026
Same author

Purkinje Cells as Gatekeepers of Seizure Susceptibility: Insights From Optogenetics.

Journal of neuroscience research·2026
Same author

Wings of Discovery: Using <i>Drosophila</i> to Decode Hereditary Spastic Paraplegia and Ataxias.

Cells·2025
Same author

Eyes Wide Open: Assessing Early Visual Behavior in Zebrafish Larvae.

Biology·2025
Same author

Gut-Brain Interactions in Neuronal Ceroid Lipofuscinoses: A Systematic Review Beyond the Brain in Paediatric Dementias.

International journal of molecular sciences·2025

Related Experiment Video

Updated: May 22, 2025

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.2K

The cerebellum in epilepsy.

Christopher Elder1, Rebecca Kerestes2, Puneet Opal3

  • 1NYU Grossman School of Medicine and NYU Langone Health, New York, New York, USA.

Epilepsia
|March 13, 2025
PubMed
Summary
This summary is machine-generated.

Cerebellar dysfunction contributes to epilepsy through various causes, impacting motor control, cognition, and affective behaviors. Understanding this link can improve epilepsy treatment and patient outcomes.

Keywords:
cerebellumepilepsyneuropathologystimulation

More Related Videos

Cerebellar Regional Dissection for Molecular Analysis
08:51

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

4.0K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.9K

Related Experiment Videos

Last Updated: May 22, 2025

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.2K
Cerebellar Regional Dissection for Molecular Analysis
08:51

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

4.0K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.9K

Area of Science:

  • Neuroscience
  • Neurology
  • Epileptology

Background:

  • The cerebellum, traditionally known for sensorimotor functions, is increasingly recognized for its role in cognition, affect, and epilepsy.
  • Cerebellar dysfunction in epilepsy arises from genetic factors, medications, seizures, and trauma, leading to symptoms like ataxia and speech deficits.

Purpose of the Study:

  • To explore the contribution of cerebellar dysfunction to epilepsy.
  • To review evidence linking genetic, infectious, and neuroinflammatory disorders to cerebellar dysfunction and epilepsy.
  • To discuss the bidirectional relationship between cerebellar dysfunction and epilepsy, including comorbidities.

Main Methods:

  • Review of data from animal studies, human neuropathology, and advanced neuroimaging techniques (MRI, PET, SPECT).
  • Analysis of electroencephalography (EEG) studies, including depth electrode recordings.
  • Examination of clinical presentations of epilepsy associated with cerebellar lesions.

Main Results:

  • Cerebellar dysfunction is evidenced by structural and functional neuroimaging, neuropathology, and animal models.
  • Cerebellar lesions can cause specific seizure types, particularly in infants with medication-resistant epilepsy.
  • Electrical stimulation of the cerebellum shows mixed efficacy, with interpretation confounded by methodological issues.

Conclusions:

  • Cerebellar dysfunction plays a significant role in epilepsy, influencing its presentation and comorbidities.
  • The relationship between cerebellar dysfunction and epilepsy is bidirectional, with seizures and therapies potentially affecting the cerebellum.
  • Advancing basic neuroscience, animal models, and patient studies will improve understanding and outcomes for epilepsy patients with cerebellar involvement.