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Updated: May 22, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Risk factors of major lower limb amputation in symptomatic peripheral artery disease: a retrospective cohort study
Supatcha Prasertcharoensuk1, Krittin Prateepphuangrat1, Phati Angkasith1
1Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Aim:
To find risk factors of major amputation in patients with peripheral artery disease (PAD) by a combination of both personal risk factors and treatment.
Methods:
This was a retrospective cohort study enrolled adult patients diagnosed as symptomatic PAD. Predictors for major amputation were analyzed.
Results:
There were 221 patients with PAD met the study criteria; 28 patients (12.67%) had major amputation events. There were three independent factors Rutherford classification, white blood cell, and serum albumin. The adjusted odds ratio (95% confidence interval) of these factors were 1.824 (1.118, 2.976), 1.073 (1.019, 1.131), and 0.421 (0.202, 0.879), respectively.
Conclusions:
Serum albumin was modifiable to prevent future major amputation in patients with PAD.
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