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Updated: May 22, 2025
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Base-Catalyzed Remote Hydrogermylation of Olefins
Eric Ahrweiler1, Aymane Selmani1, Franziska Schoenebeck1
1Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Abstract:
Although remote functionalization has emerged as a powerful strategy for modifying unactivated sites that are traditionally challenging to functionalize, there has been no remote hydrogermylation known to date. This work reports the first remote hydrogermylation of alkenes, achieved through a rare base-catalyzed approach-completely free of added transition metal catalysts. The methodology is operationally simple, versatile, and capable of achieving up to 8-carbon chain walks, overcoming the previous two-carbon limit of base-mediated processes.
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