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Updated: Jun 14, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability.

Nicole Shelley1, Bradley Judge1, Dmitriy A Yablonskiy2

  • 1Department of Neurology, Washington University in St. Louis, Saint Louis, Missouri, USA.

Annals of Clinical and Translational Neurology
|March 13, 2025
PubMed
Summary

Multiple sclerosis (MS) is associated with reduced claustrum volume, impacting neurological disability. Claustrum atrophy may be a key factor in MS-related disability progression.

Keywords:
claustrumdisabilitymagnetic resonance imagingmultiple sclerosisthalamus

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Research

Background:

  • The claustrum, a gray matter structure, has broad connectivity but its function and role in multiple sclerosis (MS) are poorly understood.
  • Pathology of the claustrum in MS is an understudied area.

Purpose of the Study:

  • To investigate whether claustrum volume is reduced in individuals with MS.
  • To determine if claustrum volume reductions correlate with specific neurological disability domains.
  • To compare the impact of claustrum volume loss to thalamic volume loss in MS.

Main Methods:

  • Analysis of data from 15,793 participants in the MS PATHS study for primary findings.
  • Validation using a separate cohort of 71 individuals with MS and healthy controls.
  • Assessment of claustrum and thalamic volumes and their association with disability measures.

Main Results:

  • Both claustrum and thalamic volumes showed similar reductions across different types of MS.
  • Reduced claustrum volume, similar to thalamic volume, was linked to impairments in walking speed, upper extremity function, and cognition.
  • Claustrum volume emerged as a stronger predictor of future disability progression compared to thalamic volume.

Conclusions:

  • Atrophy of the claustrum is a significant factor contributing to neurological disability in multiple sclerosis.
  • Claustrum pathology should be considered an important component of MS-related disability.