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Epidemiology and Survival of Marginal Zone Lymphoma in Colombian Patients: An Observational Retrospective Study
Juan F Combariza-Vallejo1, Rocío Orduz-Rodriguez2, Natalia Gomez-Lopera2
1Servicio de Hematología, Clinica Universitaria Colombia, Clinica Colsanitas S.A., Grupo Keralty, Bogotá, Colombia.
Purpose:
Marginal zone lymphomas (MZLs) are indolent non-Hodgkin lymphomas, categorized into three subtypes: extranodal, splenic, and nodal MZL (NMZL). MZL epidemiology and outcomes in Latin America remain underexplored.
Materials And Methods:
This retrospective cohort study included patients with MZL in Colombia from 2000 to 2023. Patients were followed for at least 24 months from diagnosis. The primary outcomes were real-world overall survival (Rw-OS) and real-world progression-free survival (Rw-PFS).
Results:
The cohort included 103 patients (63.1% female, 36.9% male) with a median age of 61.8 years. MALT lymphoma was the most common subtype (61.1%), followed by splenic MZL (26.2%) and NMZL (12.7%). The 60-month Rw-OS was 86.4%, and the Rw-PFS was 77.2%.
Conclusion:
MZL in Colombian patients exhibits varied clinical presentations and survival outcomes. This study underscores the importance of early detection and subtype-specific management of MZL.
