Related Experiment Video
Updated: Jul 14, 2026

13:05
Micropatterning and Assembly of 3D Microvessels
Published on: September 9, 2016
11.7K
Coils associated with micro vascular plug system for closing larger vessels: Technical note on a preliminary
Fabio Salvatori1, Cinzia Mincarelli1, Paola Piccinni2
1Interventional Radiology, Ospedale Generale Provinciale di Macerata - Ast Macerata, Macerata, Italy.
Vascular
|March 13, 2025
Summary
A new technique using the Micro Vascular Plug (MVP™) and detachable coils successfully embolizes larger peripheral vessels. This method expands MVP™ indications for vessels over 9 mm, showing 100% technical success without migration.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Medical Devices
Background:
- The MVP™ Micro Vascular Plug System is designed for peripheral vasculature embolization.
- Current limitations restrict MVP™ use to vessels ≤9 mm due to its profile and deliverability.
- A novel technique is needed to expand MVP™ applications to larger caliber vessels.
Purpose of the Study:
- To introduce and evaluate a new embolization technique using the MVP™ and detachable coils.
- To assess the feasibility of treating larger caliber peripheral vessels ( >9 mm) with this modified approach.
- To determine the safety and efficacy of this technique in preventing plug migration.
Main Methods:
- A 7-F sheath was used for MVP™ implantation without detachment.
- A microcatheter was navigated in parallel for detachable coil placement.
- Coils were anchored using the bare portion of the MVP™ to stabilize the plug and prevent migration.
- The technique was applied in two patients with larger caliber vessels.
Main Results:
- 100% technical success rate was achieved in both cases.
- No complications were reported during or after the procedures.
- No MVP™ migration was observed at the one-month follow-up.
- The technique effectively occluded the target vessels.
Conclusions:
- This novel technique successfully expands the indications for the MVP™ system.
- It enables effective embolization of peripheral vessels larger than 9 mm.
- The combined use of MVP™ and detachable coils offers a safe and stable solution for challenging embolizations.
Related Concept Videos
Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

