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Updated: May 5, 2026
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
YAP1::MAML2 Fusion Positive Epithelioid Soft Tissue Neoplasms: A Case Report and Review of the Literature
Claudia Grosse1, Petar Noack1, Alexandra Grosse2
1Department of Pathology and Molecular Pathology, Johannes Kepler University Linz, Kepler University Hospital GmbH, Linz, Austria.
None:
In the recent literature soft tissue neoplasms which harbor a recurrent YAP1::MAML2 fusion and have an epithelioid morphology with resemblance to myxoinflammatory fibroblastic sarcoma (MIFS) have been reported. In a recent series these tumors had a nodular appearance and central necrosis and were termed nodular necrotizing variants of MIFS. But their exact relationship to MIFS and their biological behavior seem to be unclear. We report a YAP1::MAML2 fusion positive nodular and necrotizing tumor with a MIFS-like morphology and provide a review of the literature.
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