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Oncogene expression in human tumors.

A G Tatosyan, S A Galetzki, N P Kisseljova

    International Journal of Cancer
    |June 15, 1985
    PubMed
    Summary
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    This study analyzed 9 oncogenes in 28 tumor types. The myc oncogene was highly expressed in several cancers, while the sis oncogene was specifically activated in lymph node metastases.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • Oncogene expression is crucial in tumorigenesis.
    • Understanding oncogene patterns in various tumors aids in developing targeted therapies.

    Purpose of the Study:

    • To investigate the expression profiles of nine key oncogenes across 28 distinct human tumor types.
    • To identify specific oncogene alterations in primary tumors versus those passaged in nude mice.

    Main Methods:

    • Analysis of oncogene expression (src, fps, mos, myc, ras, fos, sis) in 28 primary tumor types.
    • Comparison of oncogene transcription in primary tumors and human tumors xenografted into nude mice.

    Main Results:

    • The myc oncogene was transcribed in most tumors and over-expressed in specific cancers like Ewing sarcoma and kidney carcinoma.

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  • Enhanced transcription of ras and fos genes was observed across various tumors.
  • The sis oncogene was specifically activated in lymph node metastases from different tumor types.

    • Conclusions:

    • The myc oncogene shows significant expression in various cancers, suggesting its potential as a therapeutic target.
    • Specific activation of the sis oncogene in lymph node metastases highlights its role in cancer spread.
    • Differential oncogene expression patterns provide insights into tumor heterogeneity and metastatic potential.