Related Experiment Video
Updated: May 22, 2025

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
Published on: April 21, 2023
Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription
Masahiro Nagano1, Anders S Hansen2
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Abstract:
Cohesin, transcription factors (TFs), and mediator complex components regulate gene expression partly by regulating enhancer-promoter (E-P) communication. A new study combined E-P distance-controlled reporter screens with the inhibition or degradation of regulatory proteins and uncovered a distance-dependent effect across cohesin, TFs, and mediator complex components.
Related Concept Videos
RNA Polymerase II Accessory Proteins
Co-activators and Co-repressors
Master Transcription Regulators
Cooperative Binding of Transcription Regulators
Transcription Factors
The Eukaryotic Promoter Region

