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Related Experiment Video

Updated: May 22, 2025

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

Clinicopathological Significance of APC Mutation in Patient with Colorectal Cancer.

Kyoung Min Kim¹, Woo Sung Moon¹, Gi Won Ha²

¹Departments of Pathology, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea.

|March 13, 2025

Summary

This summary is machine-generated.

Adenomatous polyposis coli (APC) mutations in colorectal cancer (CRC) are linked to better survival outcomes. These mutations correlate with specific patient and tumor characteristics, suggesting a favorable prognosis.

Keywords:

Adenomatous polyposis coli Colorectal cancer Mismatch repair

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

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Last Updated: May 22, 2025

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Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

The prognostic value of Adenomatous polyposis coli (APC) mutations in colorectal cancer (CRC) is debated.
Understanding these mutations is crucial for predicting patient outcomes.

Purpose of the Study:

To investigate the impact of APC mutations on CRC prognosis.
To identify clinicopathological features associated with APC mutations.

Main Methods:

Targeted next-generation sequencing for APC mutations.
Immunohistochemical staining for mismatch repair (MMR) deficiency.
Review of clinicopathological data and histopathology.

Main Results:

APC mutations found in 72.8% of CRC patients; MMR deficiency in 8.9%.
APC mutations associated with male sex, left colon location, younger age, and lower distant metastasis.
APC mutations inversely correlated with MMR deficiency and positively with overall survival.

Conclusions:

APC mutations indicate favorable prognostic factors and improved overall survival in CRC.
Further research is required to elucidate the mechanisms linking APC mutations to better prognosis and MMR expression.