Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"My skin": a public health program for secondary school students in Spain.

Actas dermo-sifiliograficas·2026
Same author

Impact of N,N-Diethyl-meta-toluamide (DEET) and Citronella on Skin Barrier Function.

Actas dermo-sifiliograficas·2026
Same authorSame journal

New treatments for adult female acne.

Actas dermo-sifiliograficas·2026
Same author

Analysis of the Influence of Sex in 507 Patients With Moderate-to-Severe Atopic Dermatitis: Spanish Atopic Dermatitis Registry (BIOBADATOP).

Actas dermo-sifiliograficas·2026
Same author

Oncologic Safety in Solid Organ Transplant Recipients With a Past Medical History of Early-stage Melanoma: A Retrospective Cohort Study.

Actas dermo-sifiliograficas·2026
Same author

Multicenter Observational Study on Recurrence Patterns and Health Care Resource Utilization in Stage II Cutaneous Melanoma in Spain: Real-world Evidence From the METHEOR Study.

Actas dermo-sifiliograficas·2026

Related Experiment Video

Updated: May 9, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.1K

[Translated article] Multicenter, Prospective, Case-Control Study of Exposome in Melanoma.

A Navarro-Bielsa1, T Gracia-Cazaña1, M Almagro2

  • 1Dermatología, Hospital Universitario Miguel Servet, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain.

Actas Dermo-Sifiliograficas
|March 13, 2025
PubMed
Summary

This study found that increased sun exposure, certain medications, and diet are linked to melanoma risk in Spain. Prevention should focus on sun safety and healthy habits from childhood, especially for outdoor workers.

Keywords:
DietDietaEnvironmental exposureExposición ambientalExposomaExposomeMelanoma

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K

Related Experiment Videos

Last Updated: May 9, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.1K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K

Area of Science:

  • Dermatology
  • Environmental Health
  • Epidemiology

Background:

  • Ultraviolet (UV) radiation is a primary cause of skin cancer.
  • Environmental, lifestyle, and dietary factors also contribute to skin cancer development.

Purpose of the Study:

  • To investigate the association between melanoma and exposome factors in the Spanish population.
  • To identify key environmental and lifestyle risk factors for melanoma.

Main Methods:

  • Prospective multicenter case-control study.
  • Inclusion of 73 melanoma patients and 126 controls.
  • Data collection on sun exposure, medication use, and lifestyle factors.

Main Results:

  • Melanoma patients reported higher sun exposure and sunburns compared to controls.
  • Outdoor workers, history of skin cancer, and specific drug use (acetylsalicylic acid, antidepressants, ACE inhibitors) were associated with melanoma.
  • Controls utilized more protective measures like shade and clothing, and higher sun protection factor (SPF) historically.

Conclusions:

  • Sun exposure, drug intake, and dietary habits are significant exposome factors associated with melanoma.
  • Targeted prevention strategies are needed for high-risk groups, including outdoor workers.
  • Promoting sun-safe behaviors and healthy lifestyles from childhood is crucial for melanoma prevention.