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Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera
Wen-Xian Li1, Lu Gan2, Yi-Ling Liao2
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, People's Republic of China; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, People's Republic of China.
Abstract:
Linaggrenoid A (1), a highly rearranged lindenane sesquiterpenoid, together with eight undescribed lindenane sesquiterpenoid linaggrenoids B-I (2-9) and eight known analogs (10-17), were isolated from the root tubers of Lindera aggregata. Their structures, including absolute configurations, were established using spectroscopic and computational methods, as well as single-crystal X-ray diffraction. Linaggrenoids A and H (1 and 8), featuring a 5/6/3 and 3/5/6 carbocyclic ring system, respectively, demonstrated potential as anti-hepatic fibrosis agents by suppressing the expression of fibronectin, collagen I, and α-smooth muscle actin in TGF-β1-induced LX-2 cells.
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