Multidimensional Risk Factors for Heart Failure in Hispanic Adults: Findings from the All of Us Research Program

Area of Science:

• Cardiology
• Public Health
• Epidemiology

Background:

• Heart failure (HF) is a significant cause of illness and death in the U.S., impacting millions.
• HF is underdiagnosed in Hispanic adults, hindering a full understanding of their specific risk profiles.

Purpose of the Study:

• To investigate the multidimensional risk factors associated with heart failure (HF) specifically within the Hispanic adult population.
• To identify key sociodemographic, lifestyle, environmental, stress, and healthcare utilization factors contributing to HF risk in this demographic.

Main Methods:

• A cross-sectional study analyzing observational data from 5,281 Hispanic adults in the All of Us Research Program.
• Logistic regression analysis was used to identify significant risk factors for HF, adjusting for potential confounders.

Main Results:

• The prevalence of HF was 3.6% (188/5,281), with a higher prevalence in males (5.7%) than females (2.7%).
• Significant risk factors for HF included older age (OR=1.03), hypertension (OR=5.75), history of heart attack (OR=11.31), type 2 diabetes mellitus (OR=1.45), and obesity (OR=2.32).

Conclusions:

• This study identified key multidimensional risk factors for heart failure (HF) among Hispanic adults.
• Further research is recommended to compare these findings with non-Hispanic populations to inform targeted prevention strategies.