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Racial differences in primary sclerosing cholangitis: A retrospective cohort study leveraging a new ICD-10 code
Melinda Wang1, Alyssa Harris2, Charles E McCulloch3
1Department of Medicine, University of California-San Francisco, San Francisco, CA, United States.
Annals of Hepatology
|March 13, 2025
Summary
Black patients with primary sclerosing cholangitis (PSC) exhibit more severe disease indicators and receive higher-intensity care than White patients. This highlights disparities in PSC management and outcomes for Black individuals.
Area of Science:
- Hepatology
- Gastroenterology
- Health Services Research
Background:
- Limited data exist on racial disparities in primary sclerosing cholangitis (PSC).
- A new PSC-specific ICD-10 code enables contemporary nationwide cohort analysis.
Purpose of the Study:
- To characterize racial differences in PSC clinical features and outcomes.
- To compare demographic and clinical characteristics between Black and White PSC patients.
Main Methods:
- Utilized de-identified clinical/administrative data from Vizient® Clinical Data Base.
- Identified adult PSC patients using ICD-10-CM code K83.01.
- Compared outcomes between self-identified Black and White patients.
Main Results:
- Black PSC patients were more likely female, younger, and had higher comorbidity burden than White patients.
- Black patients had less concurrent inflammatory bowel disease (IBD) but more overlap syndromes.
- Black race associated with higher ICU stays and longer hospital length of stay, but similar hospitalization rates.
Conclusions:
- Black patients present with sociodemographic and clinical features suggesting more severe PSC.
- Despite similar hospitalization rates, Black patients received higher-intensity care.
- Further research is needed to address healthcare disparities in PSC for Black populations.
