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Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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Aspergillus fumigatus from Pathogenic Fungus to Unexplored Natural Treasure: Changing the Concept

Sabrin R M Ibrahim1,2, Hagar Mohamed Mohamed3,4, Anfal S Aljahdali5

  • 1Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.

Journal of Microbiology and Biotechnology
|March 13, 2025
PubMed

Insights

Aspergillus fumigatus, a significant fungal pathogen, is a rich source of diverse bioactive compounds. This review highlights its secondary metabolites, revealing potential antimicrobial, anticancer, and agricultural applications.

Area of Science:

  • Mycology
  • Natural Product Chemistry
  • Biochemistry

Background:

  • The *Aspergillus* genus, including *A. fumigatus*, comprises ancient fungi with remarkable environmental adaptability and pathogenic potential.
  • *A. fumigatus* is medically significant and possesses a vast chemical repertoire, producing diverse secondary metabolites like alkaloids, terpenes, and peptides.

Purpose of the Study:

  • To review and highlight the positive attributes of *A. fumigatus*.
  • To emphasize the structures, biological functions, and biosynthesis of metabolites isolated from *A. fumigatus*.

Main Methods:

  • Comprehensive literature review of published research on *A. fumigatus* metabolites.
  • Analysis of over 400 compounds and 145 references from 1965 to August 2024.

Main Results:

  • *A. fumigatus* produces a wide array of secondary metabolites, with alkaloids being the most common.
  • These metabolites exhibit diverse biological functions and therapeutic potential.

Conclusions:

  • *A. fumigatus* serves as a valuable reservoir of bioactive compounds.
  • Identified metabolites demonstrate significant potential for antimicrobial, anticancer, anti-inflammatory, and agricultural applications.
Keywords:
Aspergillus fumigatusFungialkaloidsbiological functionsbiosynthesislife on land

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