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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Development of a Novel Task-oriented Rehabilitation Program using a Bimanual Exoskeleton Robotic Hand
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Hand function impairment in Systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) - a longitudinal

Mark Greveling1, Voon H Ong2, Christopher Denton2

  • 1Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands m.j.greveling@umcutrecht.nl.

BMJ Open
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Systemic sclerosis (SSc) frequently causes hand impairment, impacting daily life. This study investigates risk factors and mechanisms behind SSc-related hand dysfunction to improve patient quality of life.

Keywords:
Observational StudyRHEUMATOLOGYUltrasound

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Area of Science:

  • Rheumatology and Immunology
  • Clinical Research
  • Medical Imaging

Background:

  • Systemic sclerosis (SSc) commonly leads to hand function impairment, significantly affecting patients' quality of life.
  • The precise causes of hand dysfunction in SSc remain largely unknown, highlighting a critical unmet need for effective treatments.
  • Advancements in imaging, biomarkers, and laboratory techniques offer new avenues to explore factors contributing to SSc-related hand impairment.

Purpose of the Study:

  • To identify key risk factors associated with hand function impairment in patients with systemic sclerosis (SSc).
  • To elucidate the underlying biological and clinical mechanisms driving hand dysfunction in SSc.
  • To inform the development of targeted therapeutic strategies for improving hand function in SSc patients.

Main Methods:

  • A 2-year longitudinal observational multicentre study involving patients with very early diagnosis of systemic sclerosis (SSc).
  • Comprehensive data collection including medical history, clinical status, nailfold capillaroscopy, skin assessments, and serum biomarker analysis.
  • Advanced imaging techniques such as ultrasound, elastography, and MRI will be utilized to assess hand structures and function.

Main Results:

  • Analysis will correlate various clinical, imaging, and biomarker data with objective hand function measurements.
  • Identification of specific risk factors and mechanistic pathways contributing to hand impairment in the SSc cohort.
  • Longitudinal data will reveal the progression of hand dysfunction and its relationship with disease characteristics over time.

Conclusions:

  • This study aims to provide crucial insights into the etiology of hand function impairment in systemic sclerosis.
  • Findings are expected to guide the development of novel diagnostic and therapeutic approaches for SSc-related hand complications.
  • Understanding these factors is essential for improving functional outcomes and patient well-being in systemic sclerosis.