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Metagenomic Next-Generation Sequencing-Assisted Diagnosis of Japanese Spotted Fever: Report of One Case

Ruan Yong-Chun1, Zhou Yi-Qing1, Zhang Hai-Wang1

  • 1Department of Infectious Diseases,Shaoxing People's Hospital,Shaoxing,Zhejiang 312000,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|March 13, 2025
PubMed

Insights

Japanese spotted fever, caused by Rickettsia japonica, presents with vague symptoms, risking misdiagnosis. Metagenomic sequencing identified the bacteria in a patient who then recovered with doxycycline treatment.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Genomics

Background:

  • Japanese spotted fever (JSF) is an infectious disease caused by Rickettsia japonica.
  • JSF presents with nonspecific clinical symptoms, leading to a high risk of misdiagnosis.
Keywords:
Japanese spotted feverdiagnosismetagenomic next-generation sequencing

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