Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 22, 2025

A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

20.6K

Current Methodologies to Assess Cellular Senescence in Cancer.

Panayiotis Laouris1, Daniel Muñoz-Espín2,3

  • 1Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.

Methods in Molecular Biology (Clifton, N.J.)
|March 14, 2025
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe.

Nature aging·2026
Same author

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.

Nature aging·2026
Same author

Identification of senescence-associated drivers of tumour growth and progression using a novel microarray platform.

bioRxiv : the preprint server for biology·2026
Same author

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities.

EMBO molecular medicine·2025
Same author

Feasibility study of using the PREDICT kidney tool for patients with localised renal cell carcinoma.

BJUI compass·2025
Same author

Improved Therapeutic Efficiency of Senescent Cell-specific, Galactose-Functionalized Micelle Nanocarriers.

Small (Weinheim an der Bergstrasse, Germany)·2024

Cellular senescence, a state of stable cell-cycle arrest, has a dual role in cancer. Therapies targeting senescent cells show promise, but reliable biomarkers are still needed.

Area of Science:

  • Oncology
  • Cell Biology
  • Aging Research

Background:

  • Cellular senescence is a key factor in cancer development, acting as both a tumor suppressor and promoter.
  • Senescent cells exhibit cell-cycle arrest and a senescence-associated secretory phenotype (SASP), influencing the tumor microenvironment.
  • Hallmarks include cell-cycle arrest, inflammatory factor secretion, structural changes, and metabolic alterations.

Purpose of the Study:

  • To explore the multifaceted role of cellular senescence in cancer.
  • To review methods for studying senescence in preclinical models.
  • To discuss emerging therapeutic strategies and the challenge of biomarker identification.

Main Methods:

  • In vitro assays to study senescence.
  • Ex vivo tissue analysis for senescent cell detection.
Keywords:
BiomarkersCancerCellular senescenceMethodologiesOncogene-induced-senescence

More Related Videos

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.1K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

16.7K

Related Experiment Videos

Last Updated: May 22, 2025

A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

20.6K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.1K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

16.7K
  • In vivo detection techniques in preclinical models.

    • Main Results:

    • Senescence can initially suppress tumors but may later promote cancer progression.
    • The senescence-associated secretory phenotype (SASP) significantly impacts the tumor microenvironment.
    • Senolytic and senomorphic therapies are emerging strategies for cancer treatment.

    Conclusions:

    • Cellular senescence presents a complex role in cancer, with potential for therapeutic exploitation.
    • Developing reliable, universal biomarkers for senescence detection remains a significant challenge.
    • A multimarker approach is necessary for accurate senescence characterization in diverse cancer contexts.