Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Mitochondrial Membranes

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

Socioemotional Development during Infancy

Socioemotional Development during Infancy

Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026

Same author

Plasma nectin-4 levels are associated with changes in executive function in patients with methamphetamine use disorder undergoing treatment.

Behavioural brain research·2026

Same author

De Novo MFN2 p.Arg95Met in Severe Charcot-Marie-Tooth Disease Type 2A.

Journal of the peripheral nervous system : JPNS·2026

Same author

Risk of Psychiatric Worsening With GLP-1 Receptor Agonist Use in Patients With Type 2 Diabetes and Treated Depression.

Diabetes, obesity & metabolism·2026

Same author

Residual genetic connectivity beyond shared liability in 14 psychiatric disorders.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026

Same author

Clinical Plausibility in Large Language Model Robustness Testing for Medicine: A Scoping Review.

Journal of medical systems·2026

Search research articles

Related Experiment Video

Updated: May 22, 2025

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

Exploring the interplay between mitochondrial dysfunction, early life adversity and bipolar disorder.

Cheng Ying Wu¹, Cheng-Chen Chang^2,3, Ta-Tsung Lin⁴

¹Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

International Journal of Psychiatry in Clinical Practice

|March 14, 2025

Summary

Early life adversity (ELA) is linked to mitochondrial dysfunction in bipolar disorder (BD). This study found a significant interaction between ELA and BD impacting mitochondrial DNA copy number, suggesting new therapeutic targets.

Keywords:

Bipolar disorder childhood trauma early life adversity mitochondrial DNA copy number

More Related Videos

Chronic Social Defeat Stress in Early Adolescent Male Mice

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Related Experiment Videos

Last Updated: May 22, 2025

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

Chronic Social Defeat Stress in Early Adolescent Male Mice

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Mitochondria are crucial for cellular energy and reactive oxygen species (ROS) production.
Mitochondrial dysfunction and early life adversity (ELA) are independently linked to bipolar disorder (BD).
ELA can alter mitochondrial dynamics, impacting long-term health and potentially contributing to BD pathophysiology.

Purpose of the Study:

To investigate the relationship between mitochondrial dysfunction, ELA, and BD.
To explore how ELA influences mitochondrial DNA copy number (MCN) in individuals with BD compared to healthy controls (HCs).

Main Methods:

Sixty participants diagnosed with BD and 66 HCs were recruited.
Childhood Trauma Questionnaire (CTQ) assessed ELA exposure.
Leukocyte mitochondrial DNA copy number (MCN) was quantified from blood samples.

Main Results:

The BD group reported significantly higher CTQ scores, indicating greater ELA.
A significant interaction effect was observed between ELA and BD on MCN (p=0.023).
Results suggest a critical link between ELA and mitochondrial dysfunction in BD.

Conclusions:

Findings highlight the biological underpinnings connecting ELA, mitochondrial dysfunction, and BD.
Future therapeutic strategies for BD may target mitochondrial dysfunction associated with chronic stress.
Development of pharmaceuticals to mitigate stress-induced mitochondrial issues in BD is a potential avenue.