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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Surgical resection is an effective adjunct to the management of an advanced metastatic osteosarcoma
Hani K Najm1, Samuel M Hoenig2, John P Costello1
1Pediatric and Congenital Heart Surgery, Department of Thoracic and Cardiovascular Surgery, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Insights
Surgical resection of cardiac metastatic osteosarcoma, a rare condition, can improve heart function. This case study details successful mass removal, preserving cardiac function for 12 months in advanced disease.
Area of Science:
- Cardiology
- Oncology
- Cardiac Surgery
Background:
- Cardiac metastasis from osteosarcoma is exceptionally rare.
- Limited documentation exists for the surgical management of this condition.
- Such involvement portends a poor prognosis.
Purpose of the Study:
- To describe the successful surgical resection of a cardiac metastatic osteosarcoma.
- To highlight the feasibility and potential benefits of surgical intervention.
- To present a case of extended cardiac function preservation despite advanced disease.
Main Methods:
- Resection of a large mass (approximately 3.9 x 2.2 cm) from the right atrioventricular groove and right ventricular inferolateral wall.
- Detailed description of the surgical approach and technique.
- Post-operative assessment of cardiac function.
Main Results:
- Complete resection of the cardiac mass was achieved.
- The patient maintained excellent cardiac function for 12 months post-surgery.
- Successful management of a rare metastatic cardiac tumor.
Conclusions:
- Surgical resection is a viable option for managing cardiac metastatic osteosarcoma.
- Aggressive surgical management can lead to prolonged periods of preserved cardiac function.
- This case expands the understanding of surgical possibilities in rare oncological emergencies.
Abstract:
Cardiac involvement of metastatic osteosarcoma is exceedingly rare and carries a dismal prognosis. Documentation of the surgical management of cardiac metastatic osteosarcoma is limited. We describe the successful resection of a ∼ 3.9 x 2.2 cm mass involving the right atrioventricular groove and right ventricular inferolateral wall, granting our patient 12 months of excellent cardiac function in the face of advanced metastatic disease.
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