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Updated: May 22, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Transcription Regulatory Protein SIN3 (YOL004W) Influences Mutation Rates in Saccharomyces cerevisiae
Alexandra Eftimie1,2, Damon Meyer2
1School of Medicine, University of California, Riverside, Riverside, California, United States.
Abstract:
SIN3 (YOL004W) codes for a protein in Saccharomyces cerevisiae which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition, SIN3 has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of SIN3 in affecting mutation rates within the CAN1 reporter gene, suggesting an impact on genome stability.
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