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Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseases

Yanmei Ma1,2,3, Md Munnaf Hossen1,2,3, Jennifer Jin Huang4

  • 1Rheumatology Research Institute, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Frontiers in Immunology
|March 14, 2025
PubMed

Insights

Growth arrest and DNA damage-inducible 45 (GADD45) proteins are key stress responders. This review explores GADD45

Area of Science:

  • Cellular stress response and immunology.

Background:

  • Growth arrest and DNA damage-inducible 45 (GADD45) proteins are crucial stress sensors.
  • While known for cell cycle regulation and DNA repair, GADD45 also modulates immune responses.
  • Dysregulation is implicated in inflammatory and autoimmune diseases.

Purpose of the Study:

  • To review the immunomodulatory role of GADD45 in inflammatory and autoimmune diseases.
  • To detail GADD45 expression regulation, its effects on immune cells, and signaling pathways.
  • To discuss GADD45's involvement in various disease contexts.

Main Methods:

  • Literature review focusing on GADD45 and immunity.
  • Analysis of regulatory factors influencing GADD45 expression.
  • Examination of GADD45's impact on immune cell function and signaling.

Main Results:

  • GADD45 expression is influenced by various regulatory factors.
  • GADD45 significantly impacts innate and adaptive immune cells.
  • GADD45 mediates critical signaling pathways relevant to immunity.
  • GADD45 plays a role in the pathogenesis of inflammatory and autoimmune diseases.

Conclusions:

  • GADD45 is a key player in immune system regulation.
  • Understanding GADD45's role offers therapeutic potential for autoimmune and inflammatory conditions.
  • Further research into GADD45 pathways is warranted for targeted treatments.
Keywords:
GADD45auto-immunoregulationautoimmune diseasesimmunoregulationinflammatory diseases

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