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Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
06:40

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance

Published on: July 28, 2023

Helicobacter pylori infection process: from the molecular world to clinical treatment

Meijing Yi1,2, Silan Chen1,2, Xinying Yi1,2

  • 1School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

Frontiers in Microbiology
|March 14, 2025
PubMed

Insights

Helicobacter pylori (H. pylori) causes gastrointestinal issues and gastric cancer through virulence factors and drug resistance. Novel therapies like probiotics and Chinese medicine show promise for enhanced H. pylori treatment.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Oncology

Background:

  • Helicobacter pylori is a gram-negative bacterium linked to chronic gastrointestinal disorders and gastric cancer.
  • H. pylori infection can lead to conditions such as chronic gastritis, peptic ulcers, and gastroesophageal reflux disease.

Purpose of the Study:

  • To provide a comprehensive review of H. pylori pathogenesis.
  • To highlight recent advancements in understanding virulence factors and drug resistance mechanisms.
  • To evaluate current therapeutic strategies and explore novel treatment options.

Main Methods:

  • Review of existing literature on H. pylori pathogenesis.
  • Emphasis on specific virulence factors like cytotoxin-associated gene A and vacuolating cytotoxin.
  • Examination of molecular mechanisms of drug resistance.

Main Results:

  • H. pylori employs various pathogenic mechanisms including colonization and virulence factor expression.
  • Drug resistance in H. pylori is a significant challenge in treatment.
  • Conventional therapies have limitations, prompting research into new approaches.

Conclusions:

  • Understanding H. pylori pathogenesis is crucial for effective treatment.
  • Novel therapeutic regimens, including probiotics and complementary medicine, are being investigated.
  • Further research is needed to optimize H. pylori infection management.
Keywords:
Helicobacter pyloriantibiotic resistancepathogenic mechanismprobioticstreatment

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