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Updated: May 5, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Myocardial intramural course may reduce left ventricular ejection fraction of patients suffering from coronary heart

Shi Miaomiao1, Zheng Jiaqi2, Li Xiaomeng1

  • 1Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.

Frontiers in Cardiovascular Medicine
|March 14, 2025
PubMed

Insights

Myocardial intramural course (MIC) may reduce cardiac function in coronary heart disease (CHD) patients. This anatomical variation is linked to lower left ventricular ejection fraction (LVEF), especially with increased stenosis.

Area of Science:

  • Cardiology
  • Anatomical Pathology
  • Cardiac Function Assessment

Background:

  • Myocardial intramural course (MIC) is an abnormal blood vessel routing.
  • MIC is increasingly associated with coronary heart disease (CHD).
  • The impact of MIC on cardiac function in CHD patients is not well understood.

Purpose of the Study:

  • To investigate the association between MIC and cardiac function in patients with CHD.
  • To determine if MIC contributes to impaired cardiac function in CHD patients.

Main Methods:

  • 126 patients with MIC were identified via coronary angiography and/or CT angiography.
  • 39 patients with both MIC and CHD formed the MIC-CHD group.
  • 60 CHD patients without MIC served as the control group.

Main Results:

  • Left ventricular ejection fraction (LVEF) was significantly lower in the MIC-CHD group (0.62) compared to the CHD group (0.67).
  • LVEF showed a negative correlation with the degree of systolic stenosis in mural coronary arteries (MCAs).
  • LVEF also demonstrated a negative correlation with the length of the MIC.

Conclusions:

  • MIC in conjunction with CHD may lead to reduced LVEF.
  • MIC length and MCA stenosis severity are negatively associated with LVEF in these patients.
Abstract

Keywords:
cardiac functionclinical analysiscoronary heart diseaseimaging testmyocardial intramural course

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