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Updated: May 22, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Facile, general allylation of unactivated alkyl halides via electrochemically enabled radical-polar crossover
Haifeng Chen1, Magnus Rueping1
1KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia magnus.rueping@kaust.edu.sa.
Abstract:
Electrochemically driven carbon-carbon formation is receiving considerable interest in organic synthesis. In this study, we present an electrochemically driven method for the formation of C(sp3)-C(sp3) bonds using readily available allylic carbonates, as well as primary, secondary, and tertiary alkyl bromides as electrophiles. This approach offers a highly selective route for synthesizing a broad range of allylic products with excellent functional group tolerance, all without the need for transition metal catalysts. Remarkably, this method also enables the smooth late-stage functionalization of various natural product- and drug-derived substrates, yielding the corresponding complex allylalkanes.
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