Association of clonal hematopoiesis of indeterminate potential with myocardial characteristic differences in
Jooyeon Lee1, Yoo Jin Hong2, Jin-Ho Park3
1Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Republic of Korea.
Insights
Clonal hematopoiesis (CHIP) is linked to altered heart tissue in non-ischemic heart failure (HF) patients. While CHIP affects cardiac MRI findings, its short-term impact on heart remodeling in HF is not significant.
Area of Science:
- Cardiology
- Genetics
- Aging
Background:
- Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related process impacting heart failure (HF) prognosis.
- CHIP's association with myocardial characteristics in non-ischemic HF requires further investigation.
Purpose of the Study:
- To investigate the relationship between CHIP and myocardial tissue characteristics using cardiac MRI in non-ischemic HF patients.
- To assess the impact of CHIP on left ventricular reverse remodeling in this patient cohort.
Main Methods:
- Cardiac MRI (including T1, extracellular volume, and late gadolinium enhancement) and next-generation sequencing for CHIP mutations were performed on 95 non-ischemic HF patients.
- Transthoracic echocardiography assessed left ventricular reverse remodeling.
Main Results:
- CHIP was identified in 15 patients, who exhibited higher native T1, extracellular volume fraction, and late gadolinium enhancement (LGE) on cardiac MRI.
- CHIP mutations independently correlated with cardiac MRI mapping values.
- No significant difference in left ventricular reverse remodeling was observed between CHIP-positive and CHIP-negative patients within one year.
Conclusions:
- CHIP is associated with distinct myocardial tissue characteristics, including increased mapping values and LGE, in non-ischemic HF.
- The short-term effect of CHIP on left ventricular reverse remodeling in non-ischemic HF appears attenuated.
- Further research is warranted to understand the long-term implications of CHIP in heart failure.
Abstract:
Clonal hematopoiesis of indeterminate potential (CHIP) is an aging process associated with the prognosis in heart failure (HF), regardless of etiology. This study investigated the association between CHIP and myocardial tissue characteristics in patients with non-ischemic HF. We enrolled 95 patients diagnosed with non-ischemic HF with a left ventricular ejection fraction (LVEF) of ≤40 % who underwent cardiac magnetic resonance imaging (MRI) within 3 months of diagnosis. Next-generation sequencing was performed to determine the presence of CHIP-related mutations. Transthoracic echocardiography was performed to evaluate left ventricular reverse remodeling. CHIP was identified in 15 patients. Patients with CHIP-mutation had higher native T1, extracellular volume fraction, and late gadolinium enhancement quantification (LGE). After adjusting for age and sex, CHIP mutations remained as contributing factors to the differences in cardiac MRI mapping values. However, no difference was observed in left ventricular reverse remodeling by CHIP within 1 year. This study demonstrated CHIP's association with higher mapping values and LGE on cardiac MRI. However, its impact on short-term LV reverse remodeling in non-ischemic HF patients was attenuated, indicating the need for further research on its long-term effect.
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