Triglyceride-Glucose Index Association With Severity of Coronary Artery Disease
Sara Saffar Soflaei1, Pooria Salehi-Sangani2, Zahra Fallahi3
1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
The triglyceride-glucose (TyG) index is significantly associated with coronary artery disease (CAD). Higher TyG index values indicate a greater likelihood of developing multivessel CAD, particularly in diabetic individuals.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Biomarkers
Background:
- The relationship between the triglyceride-glucose (TyG) index and coronary artery disease (CAD) requires further clarification.
- Previous studies have yielded inconclusive results regarding this association.
Purpose of the Study:
- To investigate the association between the TyG index and the presence and severity of CAD.
- To determine if the TyG index can serve as a predictive marker for CAD.
Main Methods:
- A study involving 2346 participants categorized by CAD status (no CAD, angiogram negative, single-vessel disease, two-vessel disease, three-vessel disease).
- Calculation of the TyG index using fasting triglycerides and glucose levels: Ln [fasting TG (mg/dL) × fasting glucose (mg/dL)/2].
- Analysis using adjusted regression models to assess the association between TyG index and CAD severity.
Main Results:
- Elevated TyG index significantly correlated with increased odds of having three-vessel disease (3VD), two-vessel disease (2VD), and single-vessel disease (SVD).
- Each unit increase in the TyG index was associated with higher odds of developing CAD across all severity levels compared to healthy participants.
- The TyG index also showed a significant association with CAD severity when compared to the angiogram-negative group.
Conclusions:
- The TyG index is significantly associated with the presence and severity of CAD.
- Higher TyG index values are linked to an increased likelihood of multivessel CAD, especially in diabetic patients.
- The TyG index may be a valuable biomarker for CAD risk assessment and patient stratification.
Background:
Despite previous studies, the relationship between the triglyceride-glucose (TyG) index and coronary artery disease (CAD) is still undetermined. So we aimed to investigate the association between the TyG index and CAD.
Method:
A total of 2346 subjects were enrolled in the study and were categorised into 5: those with no CAD, angiogram negative (Ang-) patients, those with single-vessel disease (SVD), or two-vessel disease (2VD) or three-vessel disease (3VD). Demographic characteristics, disease history and biochemical investigations were recorded. TyG index was calculated as Ln [fasting TG (mg/dL) × fasting glucose (mg/dL)/2].
Results:
Adjusted regression models demonstrated that the odds of 3VD (OR, 5.847; 95% CI, 4.391-7.784), 2VD (OR, 4.943; 95% CI, 3.597-6.791), SVD (OR, 4.722; 95% CI 3.448-6.647) and a negative coronary angiogram (OR, 3.137; 95% CI, 2.431-4.049), increased significantly per each unit elevation of the TyG index, compared to the healthy participants. Also, the odds for being 3VD (1.864, 95%CI 1.402-2.477, p-value < 0.001), 2VD (1.575, 95%CI 1.143-2.171, p-value = 0.005) and SVD (1.505, 95%CI 1.097-2.065, p-value = 0.011) were increased significantly by one-unit elevation of TyG index, compared to Ang- group.
Conclusion:
Our study demonstrates a significant association between elevated TyG index and the presence and severity of CAD. Higher TyG index values were consistently linked to an increased likelihood of multivessel CAD, especially in diabetic patients. These findings suggest that the TyG index could serve as a valuable marker for assessing CAD risk and stratification.
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