Prognostic significance of total metabolic tumor volume on baseline 18 F-FDG PET/CT in patients with lung adenocarcinoma: further stratification of the ninth edition of TNM staging subgroups
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Total metabolic tumor volume (TMTV) measured by PET/CT can help predict survival in lung adenocarcinoma (LUAD) patients. Incorporating TMTV may improve risk stratification within the current tumor-node-metastasis (TNM) staging system.
Area Of Science
- Oncology
- Radiology
- Medical Imaging
Background
- Lung adenocarcinoma (LUAD) prognosis is critical for treatment planning.
- The tumor-node-metastasis (TNM) staging system is standard for LUAD prognosis.
- Novel prognostic markers are needed to refine LUAD staging.
Purpose Of The Study
- To evaluate the prognostic value of baseline total metabolic tumor volume (TMTV) in LUAD.
- To assess if TMTV can further stratify patients within the TNM staging system.
Main Methods
- Retrospective analysis of 384 LUAD patients with pretreatment PET/CT.
- Determined optimal TMTV cutoff using ROC curve analysis.
- Assessed overall survival (OS) with Kaplan-Meier curves and C statistics.
Main Results
- Optimal TMTV cutoff was 40.13 ml.
- Patients with lower TMTV (<40.13 ml) had significantly better OS across stages II-IV.
- TMTV showed comparable predictive ability to TNM staging for OS.
Conclusions
- The TNM staging system is a strong prognostic tool for LUAD.
- Baseline TMTV provides additional prognostic information for risk stratification within TNM stages.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.