Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Theophylline-lithium interaction.

B L Cook, R E Smith, P J Perry

    The Journal of Clinical Psychiatry
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mental health, migration stressors and suicidal ideation among Latino immigrants in Spain and the United States.

    European psychiatry : the journal of the Association of European Psychiatrists·2016
    Same author

    An 11-year retrospective review of venlafaxine ingestion in children from the California Poison Control System.

    Human & experimental toxicology·2015
    Same author

    Increased risk of extrapyramidal side-effect treatment associated with atypical antipsychotic polytherapy.

    Acta psychiatrica Scandinavica·2006
    Same author

    Therapeutic drug monitoring of antipsychotics.

    Psychopharmacology bulletin·2002
    Same author

    DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition.

    Mini reviews in medicinal chemistry·2002
    Same author

    Nursing administration at the turn of the century.

    NursingConnections·2002
    Same journal

    Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

    The Journal of clinical psychiatry·2026
    Same journal

    Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

    The Journal of clinical psychiatry·2026
    Same journal

    Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

    The Journal of clinical psychiatry·2026
    Same journal

    Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

    The Journal of clinical psychiatry·2026
    See all related articles

    Steady therapeutic theophylline serum levels significantly impact lithium renal clearance, with considerable individual variability observed. These findings necessitate careful clinical management strategies for patients on both medications.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Clinical Therapeutics

    Background:

    • Theophylline is a common medication with known renal effects.
    • Lithium is a mood stabilizer with narrow therapeutic index and significant renal excretion.
    • Interactions between theophylline and lithium pharmacokinetics are not well-established.

    Purpose of the Study:

    • To investigate the effect of steady-state theophylline serum levels on lithium renal clearance.
    • To analyze the variability in lithium pharmacokinetics under the influence of therapeutic theophylline levels.

    Main Methods:

    • Prospective study design.
    • Inclusion of patients on stable therapeutic theophylline doses.
    • Measurement of serum lithium levels and 24-hour urine collections for lithium and creatinine.

    Related Experiment Videos

  • Calculation of lithium renal clearance.

    • Main Results:

    • Group mean lithium renal clearances and serum lithium levels showed predictable changes with theophylline administration.
    • Significant individual variability in lithium renal clearance and serum levels was observed, exceeding predicted changes.
    • Theophylline demonstrated a statistically significant effect on reducing lithium renal clearance.

    Conclusions:

    • Steady-state therapeutic theophylline serum levels can alter lithium renal clearance.
    • Individual patient factors contribute significantly to the variability in this interaction.
    • Close monitoring of serum lithium levels and renal function is crucial for patients receiving concurrent theophylline and lithium therapy.