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Generation of C(sp3)-CAr bonds in the synthesis of triarylmethanes (TRAMs): comprehensive progress since 2009
Yaqoob A Teli1, Kamal Kant1, S Aleena Chanu1
1Department of Chemistry, National Institute of Technology Manipur, Imphal 795004, India. chdeepm@gmail.com.
Abstract:
Triarylmethanes are useful compounds in materials science and medicinal chemistry. These moieties are important constituents of dyes and pharmaceuticals. These scaffolds are synthesized either by Friedel-Crafts alkylation of aldehydes and arenes or by the functionalization of diarylmethanes. The development of effective catalytic systems and the discovery of highly regio- and stereoselective methods using Brønsted or Lewis acid catalysts represent particularly important achievements in this field. This review explores the detailed documentation of the various catalytic strategies witnessed since 2009 for the synthesis of triarylmethanes, which could arouse the interest of readers in organic synthesis.
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