A mechanical approach to the longitudinal dispersion of gas flowing in human airways
Related Experiment Video
Updated: Aug 12, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
Published on: May 9, 2016
Abstract:
The aim of this work is to contribute to elucidating the mechanism underlying gas mixing in the human pulmonary airways. For this purpose, a particular attempt is made to analyse the fluid mechanical aspects of gaseous dispersion using bolus response methods. The experiments were performed on five normal subjects by injection of 10 cm3 bolus of He, Ar and SF6 into the latter part of the inspired airstream, in such a way that the whole bolus entered the inspiratory flow and was recovered during the following expiration. The results, presented in a logarithmic plot of dimensionless variance (dispersion of the output bolus) against the Peclet number, show that gaseous dispersion is only slightly dependent on the nature of the tracer gas but is strongly related to flow velocity. This is in agreement with the theory of turbulent or disturbed dispersion; however, it seems that Taylor laminar dispersion does not play a significant role in the airways.
Related Concept Videos
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion
Bernoulli's Principle: Applications
Entrainment devices use a high fluid speed to create low pressures and, thus, entrain one fluid into another. Some examples of these devices are given below:
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Physical Principles Governing Gas Exchange
Gas Laws Governing Respiration
The behavior of gases is guided by Dalton's Law of partial pressures and Henry's Law.
Dalton's Law asserts that the total pressure exerted by...
External and Internal Respiration
Application of Integration: Problem Solving

