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Related Experiment Video

Updated: Jul 15, 2026

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Association of microstructural lesions of the corpus callosum with cognitive impairment in patients with high grade

Xenia Hautmann1, Carolin Weiss Lucas2, Roland Goldbrunner2

  • 1Department of Neurosurgery, University Hospital Wuerzburg, Josef-Schneider-Str. 11, Wuerzburg, 97080, Germany. xenia.hautmann@uk-augsburg.de.

Acta Neurochirurgica
|March 14, 2025
PubMed
Summary

Fractional anisotropy (FA) in the corpus callosum (CC) can predict neurocognitive deficits in glioma patients. This white matter integrity measure offers early detection of cognitive changes, aiding treatment strategies.

Keywords:
Corpus callosumDTIGliomaNeuropsychologyWhite matter integrity

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Area of Science:

  • Neuroscience
  • Radiology
  • Oncology

Background:

  • Glioblastoma is a common malignant brain tumor.
  • Preserving neurocognitive function is crucial alongside survival.
  • Neurocognitive decline is often linked to white matter lesions.

Purpose of the Study:

  • To investigate the relationship between white matter integrity in the corpus callosum (CC) and neurocognitive deficits in glioma patients.
  • To establish reliable methods for early detection of neurocognitive changes.
  • To explore the corpus callosum (CC) as a marker for white matter (WM) integrity decline.

Main Methods:

  • Included 28 high-grade glioma patients undergoing preoperative MRI with Diffusion Tensor Imaging (DTI).
  • Utilized fsl software for MRI data processing.
  • Correlated neuropsychological parameters with fractional anisotropy (FA) in three CC regions.

Main Results:

  • Most neuropsychological parameters significantly correlated with CC fractional anisotropy (FA) preoperatively.
  • Higher FA values were associated with improved focus, memory, processing speed, and speech fluency.
  • Consistent correlations were observed between specific neuropsychological tests and CC regions.

Conclusions:

  • Fractional anisotropy (FA) of the corpus callosum (CC) is a suitable parameter for assessing the impact of distant lesions on neurocognitive abilities.
  • This method can help evaluate neurocognitive function in glioma patients.