Related Experiment Video
Updated: May 22, 2025
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Thrombin-antithrombin complex might be a promising parameter for monitoring anticoagulation in the early
Liqin Ling1, Chaonan Liu1, Jing Zhou1
1Department of Laboratory Medicine, Sichuan Clinical Research Center for Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Introduction:
Appropriate bridging anticoagulation is critical in the early postoperative period after left ventricular assist device (LVAD) implantation, because the patients are usually in a fragile balance of thrombotic to bleeding risk. Unfortunately, the ideal manner of monitoring postoperative bridging anticoagulation remains undetermined.
Methods:
Here we reported a case demonstrating that thrombin-antithrombin complex might be an option in this situation.
Results:
This patient suffered thrombosis and bleeding simultaneously within 7 days after implantation, and the 2 commonly used methods for monitoring bridging anticoagulation, activated partial thromboplastin time and anti-Xa activity, were incompatible with each other. After a multi-disciplinary team discussion, the clinicians decided to manage his anticoagulation based on thrombin-antithrombin complex level. It worked out well, and the patient was transferred to a general ward 2 weeks later.
Discussion:
With respect to clinical endpoints, thrombin-antithrombin complex might be a promising parameter for monitoring anticoagulation in the early postoperative period after LVAD implantation.
