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Updated: May 22, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Turning the kaleidoscope: Innovations shaping the future of clinical trial design
Grégoire Marret1, Mercedes Herrera1, Lillian L Siu1
1Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Abstract:
Current clinical trials are based on rigid designs and drug-centric approaches that can stifle flexibility and innovation. With advances in molecular biology and technology, there is an urgent call to revitalize trial designs to meet these evolving demands. We propose a reshaped, prismatic vision of clinical trials combining different knowledge layers, synergized with modern computational approaches. This paradigm based on iterative learning will enable a more adaptive and precise framework for oncology drug development.
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