Related Experiment Video
Updated: May 4, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
Phase-transited lysozyme coating on zirconia abutments for enhancing soft tissue seal and antibacterial activity
Li Wang1, Yang Zhou1, Yunan Zhang1
1School of Stomatology, Southwest Medical University, Luzhou, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, China; Department of Prosthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, China.
Abstract:
Zirconia abutments lacking intrinsic antibacterial properties and exhibiting inadequate sealing at the zirconia abutments-soft tissue interface may cause peri-implantitis, ultimately leading to implant failure. Simultaneously improving the soft tissue seal while integrating the antibacterial properties of zirconia abutments presents significant challenges. A phase-transited lysozyme (PTL) coating was successfully constructed on zirconia abutments to enhance soft tissue attachment and antibacterial properties, aiming to safeguard peri-implant soft tissue from infection. The PTL coated zirconia abutments boosted protein synthesis and gene expression, and facilitated the proliferation and adhesion of fibroblasts and epithelial cells. The PTL coating exhibited significant antibacterial properties against the primary pathogens associated with peri-implantitis, specifically Staphylococcus aureus and Porphyromonas gingivalis. In a rabbit immediate implantation model, a firmer gingival junctional epithelium formed around PTL-coated zirconia abutments in comparison to unmodified abutments, thereby establishing a strong soft tissue barrier against pathogen invasion. The dual-function phase-transited lysozyme coating on zirconia abutments enhances soft tissue sealing and exhibits antibacterial properties, offering a practical approach to preventing peri-implantitis.
Related Concept Videos
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Waterproofing and Anti-Bacterial Admixtures in Concrete
Waterproofing admixtures render concrete hydrophobic,...
Corrosion of Reinforcement
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...
Special Staining Techniques
Outer Layers of the Cell Envelope
Peptidoglycan Synthesis

