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Quantitation in inflammatory bowel disease using computerised interactive image analysis.

E M Thompson, A B Price, D G Altman

    Journal of Clinical Pathology
    |June 1, 1985
    PubMed
    Summary
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    Computerised image analysis distinguished ulcerative colitis and infective diarrhea from normal rectal biopsies. However, Crohn's disease remained indistinguishable, suggesting its heterogeneous nature.

    Area of Science:

    • Gastroenterology
    • Histopathology
    • Digital Pathology

    Background:

    • Distinguishing between ulcerative colitis, Crohn's disease, and infective diarrhea based on rectal biopsies is clinically significant.
    • Traditional histological assessment can be subjective and may not fully capture disease nuances.

    Purpose of the Study:

    • To objectively measure histological features in rectal biopsies using computerised interactive image analysis.
    • To determine if objective measurements can differentiate ulcerative colitis, Crohn's disease, and infective diarrhea.
    • To re-evaluate the histological description of crypt atrophy in ulcerative colitis.

    Main Methods:

    • Objective measurement of histological features in rectal biopsy specimens.
    • Computerised interactive image analysis for quantitative data acquisition.

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  • Forward stepwise discriminant analysis for statistical classification of biopsy groups.

    • Main Results:

    • Biopsies from ulcerative colitis and infective diarrhea were distinguishable from each other and normal biopsies.
    • Crohn's disease biopsies could not be distinguished from ulcerative colitis or infective diarrhea biopsies.
    • The study suggests Crohn's disease is a heterogeneous entity.
    • Apparent crypt atrophy in ulcerative colitis may be due to increased mucosal depth and altered crypt configuration.
    • The ratio of crypt cell height to surface cell height provided the best separation between Crohn's disease and ulcerative colitis.

    Conclusions:

    • Objective histological measurements can aid in differentiating some inflammatory bowel diseases and infections.
    • Crohn's disease exhibits heterogeneity, making it difficult to distinguish from ulcerative colitis using current objective histological parameters.
    • The term 'crypt atrophy' in ulcerative colitis may require re-evaluation based on observed changes in mucosal depth and crypt configuration.