Microneedle hierarchical structure construction for promoting multi-stage wound healing

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Regenerative Medicine

Background:

• Microneedles are promising for wound healing due to efficient, painless drug delivery.
• Skin's mechanical properties limit microneedle penetration, reducing drug delivery efficiency.
• Optimizing microneedle structural design is crucial for effective wound repair.

Purpose of the Study:

• To systematically review multi-level structural designs of microneedles for enhanced wound healing.
• To explore functional designs of microneedle systems across different wound repair stages.
• To provide guidance for developing smart microneedle wound management systems.

Main Methods:

• Literature review of microneedle structural parameters (single needle, array, system).
• Analysis of research on functional microneedle designs for wound repair.
• Evaluation of current microneedle patch limitations and future directions.

Main Results:

• Detailed summary of single microneedle parameters and array designs.
• Overview of microneedle system optimization strategies.
• Identification of functional designs tailored to wound healing stages.

Conclusions:

• Microneedle structural optimization is vital for overcoming skin penetration barriers.
• Functional designs can significantly improve microneedle efficacy in wound management.
• This review offers theoretical guidance for advanced microneedle wound healing technologies.