Red colour of a painful ear: red ear syndrome in paediatric age

Catarina Fernandes1, Filipe Palavra2,3

  • 1Neurology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal catarinasfernandes@hotmail.com.

BMJ Case Reports
|March 14, 2025
PubMed

Insights

This study reports a case of red ear syndrome (RES) in a child, successfully treated with indomethacin and flunarizine. It highlights the empirical nature of RES treatment.

Area of Science:

  • Neurology
  • Otolaryngology

Background:

  • Red ear syndrome (RES) is a rare disorder characterized by paroxysmal ear pain and redness.
  • Its pathophysiology remains largely unknown, and treatment is empirical.

Purpose of the Study:

  • To describe a case of red ear syndrome in a middle childhood boy.
  • To evaluate the effectiveness of indomethacin and flunarizine in managing RES symptoms.

Main Methods:

  • Cervical and brain MRI were performed to rule out other pathologies.
  • A therapeutic trial with indomethacin (75 mg/day) was initiated.
  • Flunarizine was introduced after tapering indomethacin.

Main Results:

  • MRI revealed a loop of the right anterior inferior cerebellar artery without pathological significance.
  • Indomethacin treatment led to improvement in the frequency and intensity of paroxysmal episodes.
  • Flunarizine provided a favorable response, indicating its potential efficacy.

Conclusions:

  • This case suggests that indomethacin and flunarizine may be effective treatments for red ear syndrome.
  • Further research is needed to elucidate the pathophysiology and optimize treatment strategies for RES.