Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mass Analyzers: Overview

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Perimetric Outcomes of Melbourne Rapid Field Perimetry in Patients With Glaucoma: A Systematic Review and Meta-Analysis.

Journal of glaucoma·2026

Same author

The Impact of Vision Impairment on Self-Reported Falls Among Older US Adults: Cross-Sectional and Longitudinal Study.

JMIR aging·2025

Same author

Eyelash Impalement of Iris After Uncomplicated Cataract Surgery.

Case reports in ophthalmological medicine·2025

Same author

EffUnet-SpaGen: An Efficient and Spatial Generative Approach to Glaucoma Detection.

Journal of imaging·2024

Same author

Screening for Glaucoma is Challenging but Should be Actively Pursued.

Journal of glaucoma·2024

Same author

Factors associated with glaucoma-specific quality of life in a US glaucoma clinic in a pilot implementation of an online computerised adaptive test (GlauCAT).

The British journal of ophthalmology·2022

Search research articles

Related Experiment Video

Updated: May 22, 2025

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Published on: March 3, 2023

Comparison of structure-function correlation among IMO visual function analyser and Humphrey field analyser.

Joyce Kang^1,2, Rafaella Nascimento E Silva³, Julia Anne Kim³

¹Massachusetts Eye and Ear, Boston, Massachusetts, USA.

The British Journal of Ophthalmology

|March 14, 2025

Summary

The IMO visual function analyser (IMOvifa) offers a faster glaucoma assessment than the Humphrey field analyser (HFA), with comparable structure-function correlations using optical coherence tomography (OCT). Both perimeters demonstrate moderate to strong correlations between visual field sensitivity and retinal layer thickness.

Keywords:

Diagnostic tests/Investigation Field of vision Glaucoma Optic Nerve Prospective Studies

More Related Videos

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

Related Experiment Videos

Last Updated: May 22, 2025

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Published on: March 3, 2023

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

Area of Science:

Ophthalmology
Medical Technology
Glaucoma Research

Background:

Accurate structure-function correlation is crucial for diagnosing and monitoring glaucoma.
Optical coherence tomography (OCT) provides objective measurements of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness.
Visual field testing assesses retinal sensitivity, a key functional parameter in glaucoma.

Purpose of the Study:

To compare structure-function correlations between OCT thickness parameters and visual field mean sensitivity (MS) values.
To evaluate the performance of the IMO visual function analyser (IMOvifa) against the Humphrey field analyser (HFA).

Main Methods:

Prospective cross-sectional study involving glaucoma suspects, glaucoma, and ocular hypertension patients.
Simultaneous testing with IMOvifa, HFA, and OCT within 12 weeks.
Analysis of structure-function correlations using Spearman's rank coefficient and comparison via Steiger's test, based on the Garway-Heath map.

Main Results:

The IMOvifa demonstrated significantly shorter testing times (3.7 vs 5.3 minutes) and slightly less severe visual field defects compared to HFA.
Moderate to strong correlations were found between IMOvifa and HFA MS values across sectors (p<0.001).
IMOvifa showed significant correlations with peripapillary RNFL and macular GCIPL thickness in various sectors, with no significant difference in correlation strength compared to HFA (p≥0.06).

Conclusions:

The IMOvifa is a faster alternative to HFA for visual field assessment in glaucoma patients.
Both IMOvifa and HFA exhibit comparable and significant structure-function correlations with OCT parameters.
Mean sensitivity in all sectors showed moderate to strong correlations, validating the functional assessment of retinal layers.