Cellular hyperreactivity to placenta in toxemia of pregnancy

It is generally assumed that maternal immune response may be involved in some pathological conditions of pregnancy, such as toxemia. The activity of cell-mediated immunity to placenta was studied in women with gestosis. The leucocyte inhibition technique was employed to test reactivity of peripheral blood leucocytes from postpartum women. The results indicated that leucocyte migration was significantly inhibited in the presence of placental microsomal fraction when blood from toxemic women was used. Thus, about 87% out of 30 studied cases of toxemia showed positive results. At the same time, in only 22% of women with uncomplicated pregnancy was such a positive leucocyte migration inhibition test found. There was no correlation between the severity of the toxemic symptoms and the extent of inhibition. In further experiments the leucocyte migration inhibition test with the microsomal fraction antigens from cadaver kidneys was performed; only 1 out of 6 patients showed positive leucocyte migration inhibition. These findings may suggest that the normal status of the mother is altered towards cellular hyperreactivity to placental antigens in toxemic pregnancy.