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Factors associated with lymph node metastasis and survival in T2 colon cancer

  • 0Department of Colorectal Surgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Bmc Gastroenterology +

|

March 15, 2025

|

March 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Lymph-vascular invasion and lymph node heterogeneity are key indicators for lymph node metastasis in T2 colon cancer. Identifying these factors may guide surgical decisions for improved patient outcomes.

Area Of Science

  • Oncology
  • Gastroenterology
  • Surgical Pathology

Background

  • T2 colon cancer presents a critical stage with potential for lymph node metastasis (LNM).
  • Understanding clinical factors predicting LNM and survival is crucial for treatment planning.

Purpose Of The Study

  • To identify clinical factors associated with lymph node metastasis (LNM) in T2 colon cancer.
  • To explore predictors of survival in patients with T2 colon cancer.

Main Methods

  • Retrospective analysis of 150 T2 colon cancer patients undergoing radical surgery (2017-2021).
  • Logistic and Cox regression analyses were used to identify risk factors for LNM and survival.
  • Data included demographic, radiological, pathological, and survival information.

Main Results

  • Lymph-vascular invasion (LVI) and lymph node heterogeneity were independent risk factors for LNM.
  • Patients with LNM showed significantly lower disease-free survival (DFS) (80% vs. 93.3%).
  • Elevated CA199 levels and LNM were associated with poorer overall survival (OS) and DFS.

Conclusions

  • LVI and lymph node heterogeneity are significant independent risk factors for LNM in T2 colon cancer.
  • Consideration of more extensive surgery is recommended when these risk factors are present.
  • These findings aid in risk stratification and personalized treatment strategies for T2 colon cancer.

Keywords:

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