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Comprehensive DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven

Florian Henning Geyer1,2,3,4, Alina Ritter1,2,3,4, Seneca Kinn-Gurzo5

  • 1Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

Cancer Communications (London, England)
|March 15, 2025
PubMed
Abstract

No abstract available in PubMed .

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...