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Methodological Approaches for Incorporating Marginalized Populations into HPV Vaccine Modeling: A Systematic Review.

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This summary is machine-generated.

This study reviewed 30 human papillomavirus (HPV) vaccination models, finding varied methods for including marginalized populations. Researchers recommend transparency in assumptions and more validation for HPV vaccine equity models.

Keywords:
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Area of Science:

  • Health economics and outcomes research
  • Mathematical modeling
  • Public health

Background:

  • Decision models can improve health equity by including marginalized populations.
  • Incorporating these groups requires specific assumptions in model structure and data.
  • Methodological approaches for human papillomavirus (HPV) vaccine decision models need characterization.

Purpose of the Study:

  • To characterize alternative methodological approaches for incorporating marginalized populations into HPV vaccine decision-support models.
  • To identify common strategies and assumptions used in HPV vaccination models.
  • To highlight areas for improvement in modeling equity.

Main Methods:

  • Systematic literature search (PubMed, CINAHL, Scopus, Embase, Jan 2006-June 2022).
  • Identified simulation models of HPV vaccination refining inputs for marginalized populations.
  • Extracted data on stratification, model structure, disparity attribution, calibration, validation, and sensitivity analyses.

Main Results:

  • 30 models stratified inputs by sexual behavior, HIV status, race, ethnicity, income, or rurality.
  • Five common approaches were identified, focusing on sexual behavior, cancer incidence, screening/care access, or HPV natural history.
  • Few models performed sensitivity analyses or validated outcomes for marginalized groups.

Conclusions:

  • Modelers must be explicit about assumptions and theory for marginalized populations in HPV vaccine models.
  • Greater emphasis on model validation and rigorous sensitivity analysis is needed.
  • Transparency regarding model structure and data assumptions is crucial for equity-focused modeling.