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Updated: Jul 11, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
A new standard for HCC: The high stakes of TACE-immunotherapy combinations
Antonio D'Alessio1, Lorenza Rimassa2
1Department of Surgery & Cancer, Imperial College London, London, UK.
Abstract:
Transarterial chemoembolization (TACE) has long been the standard for intermediate-stage hepatocellular carcinoma (HCC), but two recent phase 3 trials have redefined treatment paradigms. The EMERALD-11 and LEAP-0122 trials demonstrated significant progression-free survival improvement with TACE combined with durvalumab/bevacizumab or pembrolizumab/lenvatinib, respectively, but doubts remain regarding the patient selection and the toxicity of these novel combinations.
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